Abstract
The antimicrobial activity of silver nanoparticles in vitro
Highlights
THE ANTIMICROBIAL ACTIVITY OF SILVER NANOPARTICLES IN VITROIn in vitro study using the serial dilutions method in the solid medium the minimal inhibition concentration (MIC) of silver nanoparticles against such test-strains as Staphylococcus aureus MRSA ATCC 43300, Pseudomonas aeruginosa ATCC 27853, Escherichia coli ATCC 2592, Shigella sonnei, Salmonella typhimurium 144 was equal to 33.46 μg/ml
The following teststrains were used in this study: Staphylococcus aureus MRSA ATCC 43300, Pseudomonas aeruginosa ATCC 27853, Escherichia coli ATCC 2592, Bacillus subtilis ATCC 6633 and strains Shigella sonnei, Salmonella typhimurium 144 obtained from the collection of the State Research Institute of Biotechnology and Strains
All strains of microorga nisms studied were susceptible to silver nanoparticles
Summary
In in vitro study using the serial dilutions method in the solid medium the minimal inhibition concentration (MIC) of silver nanoparticles against such test-strains as Staphylococcus aureus MRSA ATCC 43300, Pseudomonas aeruginosa ATCC 27853, Escherichia coli ATCC 2592, Shigella sonnei, Salmonella typhimurium 144 was equal to 33.46 μg/ml. The antimicrobial activity of silver nanoparticles has been studied on clinical isolates with multiple drug resistance isolated from wounds, urine, endocervical and faucial scrapings in surgical patients with Klebsiella ozaenae 4348, Citrobacter freundii 4369, Escherichia coli 4358, Enterobacter aerogenes 2476, Proteus mirabilis 4363, Staphylococcus aureus 4312 and Pseudomonas aeruginosa 283. At the Pharmacology Department of O.O.Bohomolets National Me dical University the research of pharmacological and toxicological properties of different metal nanoparticles (copper, iron, silver) is carried out. In terms of continuing to study antimicrobial properties of nanosilver an experimental substance of silver nanoparticles (AgNP) with the size of 30 nm has been studied
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