Abstract
Soursop (Annona muricata) leaves are widely distributed in the tropics, including Indonesia. Soursop leaves are known to contain many anticancer compounds. Research from various countries using soursop leaves provides a different picture of the size of the dose. This research is qualitative research to determine the antiproliferative properties of soursop leaf alcohol extract on Widr cells as a model of colon cancer cells. The soursop leaves were provided from Medicinal Plant and Traditional Medicine Research and Development Center inTawangmangu. The thin-layer chromatography method was used to analyze the profile of soursop leaf extract. Microtetrazolium (MTT) proliferation test was used to analyze antiproliferative effects. The result showed that the essence quality of soursop leaves in aquoes solution was (20.65 ±0.07) % ; in ethanol solution was (19.22±0.34 ) %. The profile of ingredient soursop leaves was more visible in 366 than in 254. The ethanol extract of soursop leaves showed an antiproliferation effect at IC 50 at a dose 450 ug/ml. In conclusion, the ethanolic extract of Annona muricata showed antiproliferative properties at a dose of 450 ug/ml and having a half cell dose of IC 50.
Highlights
Annona muricata L, known as Graviola, soursop, or corossol, belongs to the Annonaceae family
Preparation for ethanol extract and aquadest extract Annona muricata Principally, the sample was extracted with ethanol extract and water-chloroform (CH3Cl), precipitated, and separated between the filtrate and residue through a filtering process
Quality of essence Annona muricata leaves based on the solvents
Summary
Annona muricata L, known as Graviola, soursop, or corossol, belongs to the Annonaceae family. The tree's shape is small to medium, which is widespread and comes from Central America.[1,2] Annona is a tropical tree with heart-like and edible, and widespread in most tropical countries. All parts of the A. muricata tree can be included in twigs, leaves, roots, fruits, and seeds. It is used for various treatments in the tropics. Fruit and fruit juices are taken to get rid of worms and parasites, cool fever, increase breast milk after childbirth, and so on astringent for diarrhea and dysentery.[3,4]
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