Abstract
Background: The secondary metabolite of medicinal plants in Polaria Tanjung Pagar’s mangrove forests and the cytotoxicity against several cancer cell lines were investigated in this study. Method: The primary materials were the methanolic extract of some medicinal plants leaves obtained from Polaria Tanjung Pagar’s mangrove forests. The thin-layer chromatography method was used to analyze the secondary metabolites qualitatively at 366 nm ultraviolet. Cytotoxicity was determined through Microtetrazolium (MTT) assay against three types of cancer cell lines, including humans’ cervical cancer (HeLa) cell lines, breast cancer (T47D) cell lines, and colorectal cancer (WiDr) cell lines. Result: All five methanolic extracts positively contained flavonoids, saponins, terpenes, steroids, phenolics, and tannins but negative alkaloids. Aegiceras corniculatum showed an active cytotoxicity against HeLa cancer cells, T47D cancer cell, and WiDr cancer cell, with IC50 of 49.40 ± 5.85, 78.12 ± 11.38, and 45.60 ± 7.35μg/mL, respectively. Avicennia alba was actively toxic to the HeLa cancer cells, T47D cancer cells, and WiDr cancer cells, with IC50 of 74.75 ± 26.97, 50.76 ± 9.92, and 73.25 ± 17.63μg/mL, respectively. Acrostichum aureum and Rhizophora mucronata only actively inhibited the WiDr cancer cell proliferation, with IC50 of 89.19 ± 4.22 and 57.49 ± 11.70μg/mL, respectively. Conclusion: Thus, mangrove forest plants scientifically potentially developed as medicinal material for cancer.
Published Version
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