Abstract
1. 1. Experiments have been performed to evaluate the role of L-glutamate diethyl ester (GDEE) and related esters as potential antagonists of L-glutamate and of the excitatory transmitter at the neuromuscular junction of the crab Eupagurus bernhardus. 2. 2. GDEE (1 μmol) was found to be a significantly ( P < 0·01) better antagonist of evoked excitatory junction potentials than L-glutamate γ-methyl ester (GME) or the other esters studied. 3. 3. GDEE was also found to antagonise the transient depolarization caused by the iontophoretic application of glutamate to the muscle fibres.
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