Abstract
Skeletal Muscle Basement Membrane-Sarcolemma-Cytoskeleton Interaction Minireview Series
Highlights
The skeletal muscle basement membrane is composed of the basal lamina and the reticular lamina
Genetic studies of muscular dystrophy patients and animal models of muscular dystrophy have demonstrated the importance of the basement membrane in maintenance of muscle integrity
New muscle fibers regenerate within a basement membrane tube, which is believed to act as a mechanical barrier to limit migration of satellite cells, and a scaffold to orient myotube regeneration
Summary
The sarcolemma (muscle plasma membrane) plays a central role in skeletal muscle structure and function [1]. Besides these well established physiological functions, the sarcolemma, subsarcolemma cytoskeleton, and surrounding basement membrane (extracellular matrix) play an essential structural role in skeletal muscle [1,2,3]. The minireview in this and the following issues updates our understanding of the structure and function of the basement membrane, cytoskeletal costameres, and the major trans-sarcolemma links (integrins and dystroglycan) in skeletal muscle.
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