The Ability of Novel Urinary Biomarkers (NGAL and IL-18) in Predicting the in-Hospital Mortality, the Need of Renal Replacement Therapy and the Future Development of Chronic Kidney Disease in Post-Cardiac Surgery Acute Kidney Injury Patients: A New Horizon of Hope on the Anvil

Jayaraman R,Gupta A,Ram P,Gupta Vk,Kanchi P,Mahapatra H,Sunder S,Sathi S,Verma H,Krishnamurthy V,Sharma N,Daksh Sk

doi:10.16966/2380-5498.194

Abstract

The Ability of Novel Urinary Biomarkers (NGAL and IL-18) in Predicting the in-Hospital Mortality, the Need of Renal Replacement Therapy and the Future Development of Chronic Kidney Disease in Post-Cardiac Surgery Acute Kidney Injury Patients: A New Horizon of Hope on the Anvil

Highlights

Acute kidney injury (AKI) is a common and serious complication of cardiothoracic surgery [1]
An adjusted 7th day IL-18 of >704.45 pg/ml predicted a mortality risk close to that observed with Neutrophil Gelatinase Associated Lipocalin (NGAL)
Urinary NGAL of 650 pg/ml predicted the need of Renal Replacement Therapy (RRT) to 85%

Summary

Introduction

Acute kidney injury (AKI) is a common and serious complication of cardiothoracic surgery [1]. In order to recapitulate the basic physiology of NGAL and IL-18, their roles and function at the molecular level, the readers are requested to have a glimpse on the background section of the first half of our study. Novel urinary biomarkers have always remained/continue to remain a fascinating area of exploration in the domain of modern nephrology. They are promisingly convincing in obviating the major disadvantages of creatinine in the setting of Acute Kidney Injury (AKI). The specific novel tubular markers include Neutrophil Gelatinase Associated Lipocalin (NGAL), Interleukin-18 (IL-18), Kidney Injury Molecule-1 (KIM-1), Hepatocyte growth factor, Osteopontin and Fatty acid binding proteins

Methods

Results

Discussion

Conclusion