Abstract
[Background]Acetaminophen or Paracetamol is widely used as analgesic and antipyretic or antimalarial drug, but at high dose it leads to undesirable side effects, such as hepatotoxicity. [Objective]This present study demonstrates the in vivo hepatoprotective effect of Thaumatococcus daniellii against acetaminophen induced liver toxicity. [Methods] Acetaminophen- induced liver injury was evaluated by an increase in serum AST (or SGOT), ALT (or SGPT), ALP activity and bilirubin level accompanied by significant decrease in albumin level. [Results] Acetaminophen hepatoxicity was manifested by an increase in lipid peroxidation, depletion of reduced glutathione (GSH) and catalase activity in liver tissue. Oral administration of the plant extract protects the rats against acetaminophen induced liver injury by increased lipid peroxidation, restored altered serum marker enzymes and antioxidant level to normal liver morphology.[Conclusion]The results showed that T. daniellii leaf extract displayed significant liver healing efficacy against acetaminophen induced hepatotoxicity in rats. The result further affirm the use of the plant as an ethno-medicinal prescription for liver related injury.
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