Evaluation of hepatoprotective activity of abelmoschus moschatus seed in paracetamol induced hepatotoxicity on rat

Abstract

Paracetamol (PCM) is widely used as analgesic and antipyretic drug, but at high dose it leads to undesirable side effects, such as hepatotoxicity. This study gives the information about hepatoprotective activity of abelmoschus moschatus seed extract against paracetamol and ethanol induced hepatotoxicity. Paracetamol induce hepatotoxicity was evaluated by an increase (P<0.05) in serum AST, ALT, ALP activity and bilirubin level Paracetamol hepatotoxicity was manifested by an increase (P<0.05) lipid peroxidation, depletion of reduced glutathione (GSH) and catalase activity in liver tissue. Administration of etanolic as well as aqueous plants extract [300mg/kg body weight of rat] protects the paracetamol induced lipid peroxidation, restored altered serum marker enzymes and antioxidant level towards normal. The results indicate hepatoprotective activity of all studied plants extract against paracetamol induced toxicity. Ethanolic extract was found more significant than the aqueous extract.