Abstract
Our study describes the possibility to deliver hTGF-β1 to human derived hamstring cells using a non-covalent bioactive strategy. The significance of our results in vivo with our functionalized biomaterial with TGF-β1-binding peptides lies in the fact that these materials can now be employed to capture endogenous TGF-β1 in a spatially-controlled manner, overcoming the need for exogenous administration of supra-physiological TGF-β1 doses. Our method is different from current solutions that rely on global TGF-β1 administration, soaking the devices with TGF-β1, etc. Therefore we believe that our method is a significant change from current state-of-the-art in the types of devices that are used for ligament/tendon repair and that following our method can endow current and future medical devices with TGF-β1 binding properties.
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