Abstract
New Zealand (NZ) young rabbits with the administration of insulin-like growth factor (IGF-1) and transforming growth factor-β (TGF-β) with and without mandibular anterior repositioning appliances are explored for the growth of the mandibular condylar cartilage (MCC). 32 growing NZ and rabbits were divided into 4 groups: the group with saline injection in TMJ, the group which received growth factor injection in TMJ, the group which received anterior positioning appliance and the group which received growth factors injection as well as mandibular repositioning appliance. Gene expression was studied by real-time RT-PCR and cartilage growth by histomorphometry. Administration of growth factors along with mandibular repositioning appliances has induced 1) 1.70-fold expression of Col-2Agene (p value 10A gene (p value growth factors along with mandibular repositioning appliances causes an increase in genetic expressions which have been corroborated by histomorphometry and validated by statistical analysis, during an accelerated growth of mandibular condylar cartilage. Administration of growth factors in the TMJ could provide a synergistic role along with mandibular repositioning appliances for treatment of mandibular retrognathism as well as disorders on the MCC.
Highlights
This MCC plays a significant role in the development of oro-facial complex and has received greater attention in orthodontics [1]
New Zealand (NZ) young rabbits with the administration of insulin-like growth factor (IGF-1) and transforming growth factor-β (TGF-β) with and without mandibular anterior repositioning appliances are explored for the growth of the mandibular condylar cartilage (MCC). 32 growing NZ and rabbits were divided into 4 groups: the group with saline injection in TMJ, the group which received growth factor injection in TMJ, the group which received anterior positioning appliance and the group which received growth factors injection as well as mandibular repositioning appliance
Histo-chemical evidence (Figure 3) confirmed an enhanced PG biosynthesis as a molecular marker enmeshed in collagen-II protein which validates the expression of Col-2A gene during the condylar growth in the young rabbits
Summary
This MCC plays a significant role in the development of oro-facial complex and has received greater attention in orthodontics [1]. Most of the studies in this regard have used either histological, histomorphometric, immuno-histomorphometric, biochemical or auto-radiographic methods as a diagnostic tool to evaluate the growth at the condyle [3,4,5,6] or detect increased expression of some growth factors/bio-markers of MCC growth [7,8,9]. These studies have provided some valuable leads at a cellular level, several questions have remained unanswered. The expression of Col-2A gene and its derivative protein (collagen II) is almost 80% component of the ECM in mice and rats whereas Type X collagen is localised in the hypertrophic and erosive zones of the condylar cartilage, where osteogenic transition takes place to facilitate endochondral
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