Abstract
A TBN-enabled tandem C-H bond oxidation/C-N bond cleavage/[3+2] cycloaddition of 1-nitromethyltetrahydroisoquinolines was realized, constructing a series of multifunctionalized isoxazole and isoxazoline skeletons in the presence of alkynes and alkenes, respectively. Various functional groups were smoothly tolerated, and the mechanistic study revealed that the construction of isoxazole and isoxazoline rings is mediated by the in situ generated nitrile oxides.
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