Abstract
Technetium-99m as pertechnetate is accumulated by the thyroid but not appreciably organified. In this study, a method of determining thyroidal uptake from the scintiscan is described. The mean uptake in euthyroid individuals as measured by this method was 1.73±0.85% with a normal range of 0.50–4.00%. Uptake was not affected by organic blocking agents. In a comparison of the overall accuracy of pertechnetate and 24-hr radioiodine uptakes, the pertechnetate uptake was slightly superior, with only 5.9% errors in 488 patients. Radioiodine uptakes were in error in 7.8% of 270 individuals. In hyperthyroid patients, the accuracy of the pertechnetate uptake was 89.6% while the radioiodine uptake had an accuracy of 75.0%. Both uptake determinations were highly inaccurate in hypothyroidism.
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