Abstract

Positron Emission Tomography (PET) is a crucial imaging modality in oncology, providing functional insights by detecting metabolic activity in tissues. Total-body PET and large field of view PET (LFOV PET) have emerged as advanced techniques, offering whole-body imaging in a single acquisition.Total-body PET enables simultaneous imaging from head to toes, providing comprehensive information on tumor distribution, metastasis, and treatment response. This is particularly valuable in oncology, where metastatic spread often requires evaluation of multiple body areas. By covering the entire body, total-body PET improves diagnostic accuracy, reduces scan time, and increases patient comfort.Furthermore these new tomographs offer a marked increase in sensitivity, thanks to their ability to capture a larger volume of data simultaneously. This heightened sensitivity enables the detection of smaller lesions and more subtle metabolic changes, improving diagnostic accuracy in the early stages of cancer or in the evaluation of minimal residual disease. Moreover, the increased sensitivity allows for lower radiotracer doses without compromising image quality, reducing patient exposure to radiation or very quick acquisistions.Another significant advantage is the possibility of dynamic acquisitions, which allow for continuous monitoring of tracer kinetics over time. This provides critical information about tissue perfusion, metabolism, and receptor binding in real-time. Dynamic imaging is particularly useful for assessing treatment response in oncology, as it enables the evaluation of tumor behavior over a period rather than a single static snapshot, offering insights into tumor aggressiveness and potential therapeutic targets.This review is focused on the current applications of Total Body and Large Field of View PET scanners in oncology.

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