Abstract
A cell culture of Taxus chinensis was found to produce taxoids in 4% yield (dry weight) after stimulation with methyl jasmonate. From the culture medium and cell mass, 16 taxoids were isolated. The structures were determined by two-dimensional gradient-enhanced DQF-COSY, HMQC, HMBC, and NOESY NMR experiments. The major taxoids of the culture were esterified at C-14 of the taxoid ring system. Five new taxoids were identified as minor metabolites and were assigned as 2α-benzoxy-4α,10β-diacetoxy-1β,7β,9α-trihydroxytax-11-ene, 2α-benzoxy-4α-acetoxy-1β,7β,10β-trihydroxy-9-dehydrotax-11-ene, 2α-benzoxy-4α,7β, 9α,10β-tetraacetoxy-1β-hydroxytax-11-ene, 2α,4α,7β,9α,10β-pentaacetoxytax-11-ene and 2α,5α,7β,9α,10β-penta- acetoxy-4β,20-epoxytax-11-ene.
Published Version
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