Abstract
Attention has been paid in recent years to studies showing immune cell death mechanisms during the course of sepsis in response to proinflammatory and anti-inflammatory mediators that are involved in its pathophysiology. Taurine (Tau) is an abundant amino acid in polymorphonuclear leucocytes that reacts with hypochlorous acid to form taurine chloramine (TauCl) under inflammatory conditions. In this context, we investigated potential interactions between lymphocytes and TauCl in rats submitted to cecal ligation and perforation (CLP), analyzing cell viability and cytokine secretion profile (TNFα, IFNγ, IL-6, IL-17A, IL-23 and IL-10).
Highlights
The project ‘HUPE against sepsis’ seeks to emphasize the importance of early recognition of sepsis, in order to accelerate the implementation of measures associated with decreased mortality for severe sepsis
The study group had greater probability to have a first dose of empirical antibiotic in less than 6 hours compared with the control group (RR 2.48; 95% cardiac index (CI) 1.88 to 3.26)
The aims of this study were to describe a population of cancer patients with severe pneumonia who required ICU admission; identify predictors of hospital mortality; and classify the study population based on ATS CAP/healthcare-associated pneumonia (HCAP) definitions providing a comparison of clinical data, microbiologic variables and outcomes between the two groups
Summary
The project ‘HUPE against sepsis’ seeks to emphasize the importance of early recognition of sepsis, in order to accelerate the implementation of measures associated with decreased mortality for severe sepsis. Materials and methods: To evaluate the reduction in time of antimicrobial adjustment therapy in patients with sepsis comparing a rapid molecular test (SeptiFast®) with conventional blood cultures, a randomized controlled clinical trial was conducted between October 2012 and May 2013 in a cardiology hospital. The aims of this study were to describe a population of cancer patients with severe pneumonia (not acquired in the hospital setting) who required ICU admission; identify predictors of hospital mortality; and classify the study population based on ATS CAP/HCAP definitions providing a comparison of clinical data, microbiologic variables and outcomes between the two groups. Materials and methods: As the diagnostic criteria of the systemic inflammatory response syndrome (SIRS) are very sensitive and very little specific, we selected patients with severe sepsis and septic shock in the first 24 hours of ICU admission, 18 years old or more, with two general and one or more inflammatory criteria of SIRS (ACCP/SCCM/2003).
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