Targeted Macrophages Delivery of Antitubercular Agent Through Solid Lipid Nanoparticles

Abstract

The objective of this paper is to summarize the current aspects related to nanoparticle targeted delivery via lipid nanoparticulate drug carrier systeM. tuberculosis ranks IInd most fatal disease after AIDS, and thus WHO declared it as “A Global Health Emergency”. Mycobacterium species source of tuberculosis infection; infects the lungs primarily and some other part of the body after infection is thoroughly spread. Antitubercular agents are classified according to their therapeutic action and safety. In this, an overview is provided on WHO-recommended treatment regimens. The study summarizes antitubercular delivery to the targeted site, i.e., macrophages via; nanoparticulate drug delivery system. Thus, the study was conducted to provide concise knowledge about nanoparticulate, solid lipid nanoparticles: introduction, advantages, components, types, preparation methods, models, parameters, characteristics, mechanism of drug release, and applications in the antitubercular delivery field. It also provides an overview of the information about macrophages, their biological role, their mechanism of action, and a few studies conducted. Macrophages act as a host body for some intracellular pathogens such as Mycobacterium species; thus, they act as an active targeted site for target-specific action. The antitubercular delivery to macrophages can reduce dosage frequency, increase solubility/permeability, bioavailability, enhance therapeutic effects, decrease toxicity, and increase patient compliance.