Target Adipose Tissue Nerves To Treat Obesity: Special Reference To β3 Adrenoceptor Agonists

Abstract

Adipocytes exist as white, brown and beige phenotype. White adipocytes are major metabolic and secretory components of the white adipose tissue, whereas brown adipocytes are responsible for non-shivering thermogenesis. A subset of white adipocytes can be activated to thermogenic beige or brite (brown in white) adipocytes. This conversion is enhanced by the drug Mirabegron, a β3 adrenoceptor agonist, resulting in improved glucose, lipid and thermogenic homeostasis. These exciting initial results could be a forerunner for additional studies on the pharmacotherapy for human obesity and related cardiometabolic disorders.