Synthesis, Structural Elucidation, In Vitro Antibacterial Activity and Antioxidant Property of a Novel Oxo‐Vanadium(V) Dimer Complex Incorporating Deferasirox Ligand

Abstract

AbstractA novel V(V) dimer complex [VO(DFX)(BuO)]2.BuOH, (DFX=deferasirox, BuOH=1‐butanol) was synthesized and fully characterized by elemental analysis, 1HNMR, 51V NMR, Fourier‐transform infrared spectroscopy (FTIR) and molar conductivity. The spectroscopically predicted structure of the synthesized Vanadium complex was also verified by single crystal X‐ray diffraction. The deferasirox ligand is coordinated to V(V) center in a tridentate fashion by two phenolate oxygen atoms and one triazole nitrogen atom, with one of the phenolates acting as bridging ligand in the dimer complex. The coordination sphere is completed by oxo group and butanolate anion. The antibacterial activities of deferasirox and its V(V) dimer complex were investigated using the zone of inhibition and the minimal inhibitory concentration of the dilution assays against Staphylococcus aureus, Bacillus cereus, Escherichia coli, and Pseudomonas aeruginosa bacteria strains. The antibiofilm potential of these compounds was also examined by evaluating their activity against biofilm formation of S. aureus and P. aeruginosa bacteria strains. Additionally, free‐radical‐scavenging ability of compounds was evaluated by their interaction with the stable free radical 2,2‐diphenyl‐1‐picrylhydrazyl (DPPH). Generally, in all assays the V(V) synthesized complex, demonstrated a moderate and selective activity.