Acetohydroxamate-coordinated Oxovanadium(V) Complexes with Halide Containing Hydrazones: Synthesis, Characterization, X-ray Crystal Structures, and Antibacterial Activity

Abstract

Two oxovanadium(V) complexes, [VO(L)(L1)] (I) and [VOLL2] (II), where L = acetohydroxamate, H2L1 = 2-bromo-N'-(2-hydroxybenzylidene)benzohydrazide, H2L2 = 2-chloro-N'-(2-hydroxybenzylidene)benzohydrazide,have been synthesized by reaction of VO(Acac)2 with acetohydroxamic acid and hydrazone ligands, and characterized by elemental analyses, IR, UV-Vis, 1H NMR, molar conductivity, and X-ray single crystal structural determination (CIF file CCDC nos. 1911887 (I), 1911888 (II)). The hydrazone ligands coordinate to the V atoms through phenolate oxygen, imino nitrogen, and enolate oxygen atoms. The acetohydroxamate ligand coordinate to the V atoms through the two oxygen atoms. The V atoms are in octahedral coordination with the sixth site coordinated by an oxo group. The antibacterial property of the complexes and the hydrazones against the bacteria B. subtilis, E. coli, P. putida, and S. aureus were studied. Both complexes exhibit remarkable antibacterial properties on B. subtilis and S. aureus comparable to Penicillin.