Synthesis, structural elucidation, catalytic, pharmacological and α-glucosidase inhibitory studies of metal complexes with flavone derivatives as emerging biomaterials

Abstract

The pharmacologically active structural architecture of conjugative heterocyclic structure core comprised of flavone derivative (obtained by the condensation of substituted flavone with 4-methoxy-o-phenylenediammine) with different metal acetates to arrive different chelates with molecular formulae of [M 2+ L(OAc) 2 ] where L = flavone derivative, M = Cu 2+ , Ni 2+ , Co 2+ and Zn 2+ . The structural features of synthesized compounds using elemental compositions, molar conductivity, magnetic properties, electronic absorption, vibrational frequencies, proton assignments, ESR, thermal analysis and cyclic voltammetry protocols. On the basis of spectroscopic approaches demonstrated that a square planar geometry for above metal chelates. The catalytic activities of various copper complexes were designed to mimics the natural copper enzymes that facilitate oxygen towards oxidation process were investigated. The catalytic conversion of benzyl alcohol into benzaldehyde and to optimize the reaction situations was performed to attain enhanced turn over number. The DNA binding efficiency was performed using electrochemical technique demonstrated that the metal chelates were chemically bonded with DNA through intercalation mode. The prepared metal chelates were assessed for antimicrobial efficiency with B. subtilis, E. coli, S. aureus, C. albicans, A. niger and A. flavus . The observed outcomes were specified that the chelates showed improved antimicrobial efficiencies than ligand. Additionally, the SOD biomimetic activity of prepared metal complexes was measured and discussed. Antituberculosis efficiencies of ligand and its chelates was assessed against M. tuberculosis H37Rv strain with the help of MABA protocol. The prepared metal chelates were subjected to α-glucosidase inhibitory efficiency and its salient features are summarized.