Synthesis, characterization and biochemical studies of redox active metal complexes with flavone derivative

Abstract

In the present investigations was focused on the synthesis of flavone derivative (obtained by the condensation of substituted flavone with o-phenylenediammine), dppz with different metal acetates to arrive different mixed ligand metal chelates with molecular formulae of [ML(dppz)]0.2(OAc) where L = flavone derivative; M = Cu(II), Co(II), Ni(II) and Zn(II), respectively. The structural compositions and arrangements were inferred based on elemental compositions, molar conductivity, magnetic properties, electronic absorption, vibrational frequencies, proton assignments, ESR, thermal analysis and cyclic voltammetry protocols. On the basis of spectroscopic approaches established that square planar arrangement for Cu 2+ , Ni 2+ , Co 2+ and Zn 2+ chelates. The DNA cleavage efficiency was performed using agarose gel permeation technique revealed the metal chelates were interacted with DNA induced DNA denaturation. The prepared metal chelates were assessed for antimicrobial efficiency with B.subtilis, E. coli, S.aureus, C. albicans, A.niger and A.flavus . The observed research outcomes were indicated that metal chelates exposed improved antimicrobial efficacies than ligand. Furthermore, SOD biomimetic activity of prepared metal complexes was performed and presented. Antituberculosis competences of ligand and its chelates was assessed against M. tuberculosis H 37 Rv strain with the help of MABA protocol. The prepared metal chelates were subjected to α-glucosidase inhibitory efficiency, anti-inflammatory activity and presented.