Synthesis, Spectroscopic Characterization, DNA Binding Ability and Biological Activities of Transition Metal Complexes Containing Tridentate Schiff base

Abstract

A new series of transition metal complexes of Cu(II),Ni(II),Co(II),and Zn(II) have been synthesized from the Schiff base (L) derived from1,3- isopthaldehyde with 2-amino phenol and 4-Nitroaniline. Its Cu(II), Co(II), Ni(II), Zn(II) complexes have also been synthesized in ethanol medium. The structural features have arrived from their elemental analyses, molar conductance, magnetic susceptibility, IR, UV–Vis, mass, ESR and 1H NMR spectral studies. The data show that the complexes have composition of ML2 type. The electronic absorption spectral data of the complexes suggest an octahedral geometry around the central metal ion. The interaction of the complexes with calf thymus (CT) DNA has been studied using absorption spectra, and Cyclic Voltammetric measurement. The metal complexes exhibit effective cleavage of pBR 322 DNA from the super coiled form to the open circular form. These complexes also show enhanced antifungal and antibacterial activities compared with the free ligand