Abstract
Ofloxacin is a quinolone antibiotic that is considered an efficient antibacterial drug with a broad spectrum of activity against anaerobic and aerobic bacteria and has strong antibacterial activity in vitro against many bacteria species by inhibiting their DNA-gyrase. In this study, the synthesis, physicochemical and spectroscopic characterization of Cobalt (II) metal complex with ofloxacin as primary ligand and ascorbic acid as the secondary ligand have been carried out. The complex was prepared by reflux method for four hours in methanol. The complex, with the molecular formula [Co(Ofl)(Asc)], was characterized by its color, solubility, melting point, FTIR, UV/Visible, 1H NMR, and 13C NMR spectroscopy. The color and the melting point suggest that complexation occurred. The Fourier Transform Infrared data for both the primary ligand (Ofl) and the secondary ligand (Asc) acted as tridentate ligands. Ofl coordinated to the Co(II) metal ion via the two carbonyl oxygen atoms and the oxygen atom of the hydroxyl group, whereas Asc coordinated to the metal through the carbonyl and enolic C-2 and C-3 hydroxyl groups. The electronic data suggests octahedral geometry for the complex. The ligands and the novel Co (II) complex were tested for in vitro antibacterial activity against gram-negative and gram-positive bacterial species using the filter paper disc agar diffusion method. Significant antibacterial activities were observed for the complex compared to the ligands. This research will aid in the development of more potent drugs that are resistant to organisms.
Highlights
Ofloxacin is a quinolone antibiotic that is considered an efficient antibacterial drug with a broad spectrum of activity against anaerobic and aerobic bacteria and has strong antibacterial activity in vitro against many bacteria species by inhibiting their DNA-gyrase. [1, 2, 3]
A large number of mixed-ligand complexes from primary ligands such as gemifloxacin, flumequine, lomefloxacin, norfloxacin, oxolinic acid, and enrofloxacin with some nitrogen donor heterocyclic ligand, such as 1,10phenanthroline (Phen),2,2’-bipyridine (Bipy), and amino acid such as glycine (Gly) acting as secondary ligand have been synthesized with Zn(II), Zr(IV), La(III), Ce(III), Ce(IV), Th(IV), Sn(II), and U(VI) metal ions have been reported [7 – 9]
A lot of metal complexes of ofloxacin have been reported in combination with other ligands, no report has been reported in the literature for the Co(II) mixed ligand complex of ofloxacin and ascorbic acid
Summary
Ofloxacin is a quinolone antibiotic that is considered an efficient antibacterial drug with a broad spectrum of activity against anaerobic and aerobic bacteria and has strong antibacterial activity in vitro against many bacteria species by inhibiting their DNA-gyrase. [1, 2, 3]. Researchers have recently been attempting to develop novel chemical compounds to prevent bacterial resistance to an antibiotic, which is one of the most serious issues confronting the medical community [4]. One of such discoveries is the complexation of drugs with metal ions which improves the pharmaceutical profiles of these drugs. The antibacterial activities of Co(II) and Ni(II) mixed complexes of ofloxacin with 1,10-phenanthroline (phen)/2,2'-bipyridine (bipy) have been reported [4]. The study includes antibacterial activities of the synthesized complex and the ligands against some bacterial species The results of these investigations are reported in this article
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
