Preparation of Mixed ligand Complexes of Heterocyclic Azo Quinoline Ligand and Imidazole Molecule with Some of Divalent Transition Ions and their Biological Activity Against Multi Drug Resistance Pathogenic Bacteria

Abstract

Heterocyclic azo compound 2-(8-quinolyl azo)-4,6-dimethyl phenol as a primary ligand and imidazole molecule as a secondary ligand in the basic medium were prepared with novel mixed ligand complexes of Hg(II), Mn(II), Ni(II), Co(II) and Cu(II) ions, these compounds were characterized by Mass, 1HNMR, IR, UV-Vis, Magnetic susbtibility and Molar Conductivity, which suggested octahedral conductivity. Free ligands and five mixed ligand complexes of Hg(II), Mn(II), Ni(II), Co(II) and Cu(II) metal ions with a general formula of [M(L1)(L2)2C1] against eight pathogenic multidrug resistance bacteria, six G-ve bacteria (Pr. mirabilis, S. typhi, E. coli, P. aeroginosa, A. baumanii and K. pneumoniae) and two G+ve bacteria (E. faecalis and S. aureus) were capable of antimicrobial efficacy. The findings show that free ligands have had stronger antibacterial activity on S. Bacterial isolation of typhi and P. aeroginosa relative to other isolates. As for the effectiveness of metal complexes, compared to G+ve bacteria, they usually have a large antibacterial effect on G-ve bacteria, whereas the Hg(II) ion complex has a higher antibacterial effect on most bacterial isolates compared to other metal complexes. Compared with other metal complexes, Mn (II) ion complexes demonstrated poorer antibacterial activity..