Synthesis of Unsymmetrical Fréchet-type Dendrimers via Double Click Chemistry

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dendrimers. 2 The convergent methodology installs the core in the final step, enabling the incorporation of functionalities. It provides greater structural control than the divergent approach due to its relatively low number of coupling reactions at each growth step. Future applications of dendrimers rely on efficient and practical synthetic procedures. Therefore, development of a versatile methodology to render the synthesis of dendrimers more adaptable to specific needs is necessary. The last decade has witnessed the rapid growth of the click chemistry which is the coppercatalyzed azide-alkyne cycloaddition reaction developed by