Abstract
The synthesis of thioamides via the condensation reaction of thiocarboxylic acids with amines is described. Using 3-cyano-1,2,4-triazole as a favorable nucleophilic catalyst and 3-cyano-1,2,4-triazol-1-yl-tris(pyrrolidine-1-yl)phosphonium hexafluorophosphate (PyCTP) as a new phosphonium-type condensing reagent, thioamides are obtained selectively over amides, which can be attributed to the hardness of the phosphorus center of the condensing reagent.
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