Synthesis of 3-Hydroxy-2-hydroxy(phenyl)methyl-3-methyl-2,3-dihydro-4H-furo[3,2-c]chromen-4-one from 4-Hydroxycoumarin

Abstract

4-Hydroxycoumarin derivatives include a number of compounds exhibiting biological activity. An important place in this series is occupied by furocoumarins possessing diverse pharmacological properties: antifungal, zoocidal, anticoagulant, spasmolytic, etc. [1–6]. Furocoumarins can be isolated from natural sources [7] or synthesized [8–11]. Methods of synthesis of furocoumarins are based on C-alkylation of 4-hydroxycoumarin with α-halo ketones or halo alkynes with subsequent cyclization [9, 10] or on oxidative addition of olefins to 4-hydroxycoumarin in the presence of silver(I) salts [11].