Synthesis of (3,4-bis{[2-hydroxy-3-methoxy-5-(4-methylphenyl azo)benzylidene]-amino}phenyl) phenyl methanone as a novel azo Schiff base

A Jarrahpour,M Zarei

doi:10.3390/m376

Abstract

Schiff bases are used as substrates in the preparation of a large of bioactive and industrial compounds via ring closure, cycloaddition, replacement reactions, etc [1].[...]

Highlights

Azo aldehyde 2 was synthesized according to a reported method [17]
The resulting mixture was stirred for 6 hours at room temperature [18]
The solvent was evaporated under reduced pressure to give azo Schiff base 3 as a red solid which was recrystalized from ethanol 95% (1.28 g, 91 %)

Summary

Introduction

Azo aldehyde 2 was synthesized according to a reported method [17]. To a stirred solution of azo aldehyde 2 (1.08 g, 3.76 mmol ) in dry CH2Cl2 (30.00 mL) at 0 oC were successively added (3,4-diaminophenyl)phenyl methanone 1(0.40 g, 1.88 mmol) and a excces of anhydrous MgSO4 (2.00 g,16.67 mmol). Azo aldehyde 2 was synthesized according to a reported method [17].

Results

Conclusion