Abstract
A new compound, 4,6-diamino-5-(methylbenzylidene)pyrimidin-2(5H)-one, was synthesized and its IR, 1H NMR,13C NMR and MS spectroscopic data are presented.
Highlights
A new compound, 4,6-diamino-5-(methylbenzylidene)pyrimidin-2(5H)-one, was synthesized and its IR, 1H NMR,13C NMR and MS spectroscopic data are presented
Pyrimidines and their derivatives are considered an important group of compounds because of the diversity of biological activities associated with these systems
The Biginelli reaction is a well-known multicomponent reaction involving a one-pot cyclocondensation of an aldehyde, a methylene active compound and urea/thiourea for the synthesis of pyrimidine derivatives [13,14,15]
Summary
A new compound, 4,6-diamino-5-(methylbenzylidene)pyrimidin-2(5H)-one, was synthesized and its IR, 1H NMR,13C NMR and MS spectroscopic data are presented. Gricela Lobo 1,*, Jaime Charris 1, Margaret Valderrama 1, Jesús Romero 1, Cristina Castelli 2 and Antonieta Taddei 2 Laboratorio de Síntesis Orgánica, Facultad de Farmacia, Universidad Central de Venezuela, Caracas 1051, Venezuela; E-Mails: jaime.charris@ucv.ve (J.C.); mjvalderr@yahoo.es (M.V.); ucvromeroj@gmail.com (J.R.) Departamento de Biología Celular, Universidad Simón Bolívar, Caracas 1080, Venezuela; E-Mails: ccastelli.castelli@gmail.com (C.C.); ataddei@usb.ve (A.T.)
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