Abstract
2-Chloro-4-(3-nitrophenoxy)-6-(thiophen-2-yl) pyrimidine (c) is an important intermediate of small molecule anticancer drugs. In this paper, a rapid synthesis method for the target compound has been developed. Compound c was synthesized from 2,4,6-trichloropyrimidine (a) through two steps including nucleophilic substitution and coupling reaction. The structure of the target compound c was confirmed by 1H NMR and MS spectrum. Furthermore, the synthetic method was optimized. The total yield of the two steps was up to 44.6%.
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