Abstract
2, 4-dichloro-6-(3-nitrophenoxy) pyrimidine is an important intermediate of small molecule anticancer drugs. In this work, a rapid synthetic method for target compounds was established. Compound (4) was synthesized from methyl 3-aminothiophene-2-carboxylate and urea through three steps including cyclization, chlorination and nucleophilic substitution. The structure of the target compound was confirmed by 1H NMR and MS spectrum. Furthermore, the synthetic method was optimized. The total yield of the three steps was 42.4%.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: IOP Conference Series: Earth and Environmental Science
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
