Abstract
7-fluoroquinazoline-2, 4-diol is an important intermediate of small molecule anticancer drugs. In this work, a rapid synthetic method for target compounds was established. Compound (4) was synthesized from 2-amino-4-fluoro benzoic acid and urea through three steps including cyclization, chlorination and nucleophilic substitution. The structure of the target compound was confirmed by H NMR and MS spectrum. Furthermore, the synthetic method was optimized. The total yield of the three steps was 51%.
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