Synthesis, Molecular Docking and Antimicrobial Studies of Some Novel 1,4-Dihydropyridine Derivatives

Abstract

Three components one pot synthesis of some novel triazole substituted 1,4-dihydropyridine compounds from the simple condensation reaction of ethyl acetoacetate, 4-amino triazole and aromatic aldehyde has been demonstrated using on low cost and efficient acetic acid catalyst in solvent free condition followed by microwave irradiation method. The newly synthesized 1,4-dihydropyridine compounds exhibit in excellent yield. The synthesized dihydropyridine derivatives are screened for antimicrobial properties and molecular docking study.