Abstract
Newscaffolds consists of 1,2,3-triazole linked quinoline derivatives (9a-l) were synthesized and confirmed by 1H NMR, 13C NMR and ESI-MS spectra. Using the MTT assay and doxorubicin as the standard dugs, all the synthesized compounds were further investigated for their anticancer efficacy against the two cancer cell lines, HT-1080 and A-549. When compared to doxorubicin, compounds 9c, 9j and 9d showed the strongest efficacy against the tested cancer cell lines, HT-1080 and A-549. Using the PyRx tool’s Autodock Vina, the molecular docking investigations on enoyl reductase were carried out. It is interesting to note that the interactions and binding energies determined by docking molecules match the data under investigation.
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