Abstract
A series of 3,4-dihydro-4,6-diaryl-2-pyrimidinethiones was obtained using a three-component reaction and their modifiaction with dimethyl chloroethynylphosphonate was performed. It was shown that the phosphonylation reaction occurs under mild conditions and chemo- and regioselectively leads to bicyclic products, namely dimethyl 5,7-diaryl-5H-thiazolo[3,2-a]pyrimidine-3-phosphonates. Antimicrobial activity of the synthesized compounds against Staphylococcus aureus and Pseudomonas aeruginosa bacteria and yeast-like fungi Candida utilis was studied.
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