Abstract

ABSTRACTOrganotin complexes of type R2SnClL [where L = Schiff base obtained by the condensation of 2-(4-Bromo/Chloro-benzyloxy)-3-methoxy-benzaldehyde and nicotinic/isonicotinic hydrazides; R = Me, Et, Bu, and Ph] have been synthesized and characterized by elemental analysis, molar conductance, infrared and NMR (1H, 13C, and 119Sn) spectral analyses. The ligands and their organotin complexes have been evaluated for antimicrobial activity and the QSAR studies indicated that antimicrobial activity of target compounds is governed by total energy of molecule and topological descriptors.

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