Synthesis, characterization and antimicrobial studies of organotin(IV) complexes of N-methyl-N-phenyldithiocarbamate

Abstract

Abstract Organotin(IV) dithiocarbamate complexes have shown a large spectrum of biological activities, which includes antioxidants, anti-inflammatory, antimicrobial, antituberculosis, anticancer and antiviral. In this report, organotin(IV) dithiocarbamate complexes derived from N-methyl-N-phenyldithiocarbamate (L) and organotin have been synthesized. The complexes which were represented as C4H9(Cl)SnL2 (1), C6H5(Cl)SnL2 (2), (CH3)2SnL2 (3), (C4H9)2SnL2 (4) and (C6H5)2SnL2 (5), were characterized by spectroscopic techniques (FTIR, 1H, 13C and 119Sn NMR), elemental and thermal analyses (TGA and DTG). The structures of complexes (3) and (4) were further established by X-ray single crystal diffraction. The structures, in both complexes, gave a distorted octahedral geometry around the tin center. This is due to the longer bond length of one of the Sn S bonds within the complexes compared to others, and also the electronic and steric demands caused by the alkyl substituents on the tin atom. The complexes exhibited varied antimicrobial activity against S. Aureus, B. cerues, K. pneumonia, P. aeruginosa, E. coli, C. albican and A. flavus. Complex 5 displayed the best antimicrobial activities compared to the other organotin complexes, and this could be attributed to the planar phenyl group attached to the tin center causing an increase in the lipophilicity of the complex through the lipid bilayer of the bacteria organisms.