Synthesis, Characterization, and Antibacterial Activities of Organotin(IV) Complexes with 2‐Acetylpyridine‐N(4)‐cyclohexylthiosemicarbazone (HAPCT)

Abstract

ABSTRACTThe reaction of 2‐acetylpyridine‐N(4)‐cyclohexylthiosemicarbazone [(HAPCT), (1)] ligand with organotin(IV) chloride(s) afforded the five new organotin(IV) complexes: [MeSnCl2(APCT)] (2), [BuSnCl2(APCT)] (3), [PhSnCl2(APCT)] (4), [Me2SnCl(APCT)] (5), and [Ph2SnCl(APCT)] (6). The ligand (1) and its organotin(IV) complexes (2–6) have been synthesized and characterized by CHN analyses, molar conductivity, UV–vis, FT IR, 1H, 13C, and 119Sn NMR spectral studies. The single crystal X‐ray diffraction studies indicated that [PhSnCl2(APCT)] (4) is six coordinated and strongly adopts a distorted octahedral configuration with the coordination through pyridine‐N, azomethine‐N, and thiolato‐S atoms of the ligand. The compound crystallizes into a monoclinic lattice with the space group P21/n. The ligand (1) and its organotin(IV) complexes (2–6) were assayed for in vitro antibacterial activity against Staphylococcus aureus, Escherichia coli, Enterobacter aerogenes, and Salmonella typhi. The screening results have shown that the organotin(IV) complexes (2–6) have better antibacterial activity than the free ligand. Furthermore, it has been shown that the diphenyltin(IV) derivative (6) exhibits significantly better activities than the other organotin(IV) derivatives (2–5). © 2012 Wiley Periodicals, Inc. Heteroatom Chem 24:43–52, 2013; View this article online at wileyonlinelibrary.com. DOI 10.1002/hc.21061