Abstract
Majority of bio-molecules exist in nature are complex compounds and exhibits profound biological activity. The crystalline Nickel complexes are gained lot of attraction due their strong anti leukemic activity. The synthetic protocol of 2-Amino-benzimidazole (I) condensation with acetyl acetone, ethylcyanoacetate and 3, 4-dimethoxy benzaldehyde established to develop Schiff Bases ((IIa) C19H18N6, (IIb) C12H12N4O & (II c) C16H15N3O2). Schiff Bases were condensed with Nickel(II) Chloride to form Nickel complexes (IIIa,IIIIb,.IIIc). The prepared Ni (II) complexes were characterized by elemental analysis and spectroscopic analysis with IR, 1HNMR, UV-Visible. The antimicrobial activity of the ligands [IIa, IIb and IIc] and their Ni(II) complexes [IIIa, IIIb, IIIc] against bacterial strains and fungal strains were investigated. The antimicrobial activity of the prepared crystalline metal complexes and the ligands were also discussed.
Published Version
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