Abstract

A Schiff base ligand has been synthesized by the condensation of 2-aminopyridine and 2- methoxybenzaldehyde. Metal complexes of the Schiff base were prepared by the reaction of the Schiff base and metal (II) chlorides of cobalt and nickel in ethanol. The complexes were isolated, washed and dried. The Schiff base is pale yellow, while cobalt and nickel complexes are blue and light green respectively. The Schiff base and its metal (II) complexes were characterized by solubility test, melting and decomposition temperature determination, FTIR, magnetic susceptibility, molar conductance gravimetric analysis and UV spectroscopy. Solubility test carried on the Schiff base and the complexes showed that they are all soluble in DMSO and DMF, but insoluble in water. From the FTIR result, a peak at 1577cm-1 is assigned to the azomethine of the Schiff base which shifted to 1637 and 1622 cm-1 in cobalt (II) and nickel (II) complexes respectively. The complexes are high spin, non electrolytic in nature and have high thermal stability. Job’s method of continuous variation suggests 1:2 metal to ligand ratio. The Schiff base is inactive against Staphylococcus aureus at all concentrations while the complexes were found to be active and the activity increases with increase in concentration. The Schiff base and its complexes are found to be active against E. coli at all concentrations. The anifungal study revealed that the Schiff base and its complexes are active against Candida albican at all concentrations, but inactive againstMucor specie at all concentrations.KEY WORDS: 2-aminopyridine, 2-methoxybenzaldehyde, Ligand, Characterization, Antimicrobial activity

Talk to us

Join us for a 30 min session where you can share your feedback and ask us any queries you have

Schedule a call

Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.