Synthesis, characterization and in vitro antitumour activity of a series of substituted 2,2‐di‐n‐butyl‐4‐oxo‐benzo‐1,3,2‐dioxastannins

Abstract

AbstractThe characterization by 1D and/or 2D 1H NMR, 13C NMR, 119Sn NMR, Mössbauer and mass spectrometry of a series of di‐n‐butyltin derivatives of 3‐, 4‐, and 5‐methyl‐, 3‐, 4‐, and 5‐methoxy‐, 4‐ and 5‐amino‐substituted, and 3,5‐diiodo‐salicyclic acids is described. Their NMR spectra suggest that they are present as dimers in CDCl3 solution, like the di‐n‐butyltin derivative of unsubstituted salicyclic acid. This has been confirmed by the observation of mixed dimers. The insoluble derivatives have been characterizerd by solid state cross polarization/magic angle spinning (CP/MAS) 13C and/or 119Sn NMR, Mössbauer and mass spectroscopy. These compounds are characterized in vitro by a lower inhibition dose than cis‐platin or etoposide against a series of five human cell lines.