Synthesis, Characterization and Antibacterial study of some 1, 3, 4- thiadiazole ring appended azo derivatives

Abstract

A series of 1,3,4-thiadiazole ring appended azo derivatives were synthesized in good yields via diazo coupling reaction between 5-(4-substituted)-1,3,4-thiadiazole-2-amine and some active methyline compounds such as dimedone and acetylacetone. All the synthesized compounds were characterized by FT-IR and 1HNMR spectroscopic methods. Further, all synthesized compounds were screened for the antibacterial activity against gram negative bacteria (Escherichia coli, Pseudomonas aruginosa, Shigella boydii) and gram-positive bacteria (Staphylococcus aureus, Bacillus megaterium). The thiadiazole ring appended azo derivative containing a chloro group showed potent activity against Shigella boydii (67.85%) and Staphylococcus aureus (78.57%) and the compound having a nitro group in its structure exhibited maximum zone of inhibition against Staphylococcus aureus (89.28%) and Shigella boydii (82.14%).