Abstract
This work identified a summary of new chalcone derivatives (E)-2-(4-acetamidophenoxy)-N-(3-(3-(4-substitutedphenyl) acryloyl) phenyl) acetamide by the condensation of 2-(4-acetamidophenoxy)-N-(3-acetylphenyl) acetamide with various aromatic aldehydes. Synthesized compounds were characterized by IR and 1H NMR spectroscopy. Several bacterial species and also candida albicans were tested for the antimicrobial activity. Compared to the standard drug streptomycin and clotrimazole against bacterial and fungal species, 5e, 5c and 5d have shown strong antibacterial and moderate antifungal activity. The aim of the anti - microbial agent enzyme was to investigate and describe the interactions of the identified hits within the target enzyme binding pocket using the synthesized composite against glucosamine-6 phosphorus synthase. The docking results enhanced the behaviour of new derivatives as promising antimicrobials. The simulation of (E)-2-(4-acetamidophenoxy)-N-(3-(3-(2-chlorophenyl) acryloyl) phenyl acetamide (5a) in BRCA1 resulted in the creation of two hydrogen bond interactions with bond distance (2.13 Å) and it was observed that the best binding energy value for −9.07Kcal / mol,
Published Version
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