Abstract
Fungal infections in transplant recipients: pros and cons of immunosuppressive and antimicrobial treatment
Highlights
Recipients of solid-organ transplants or haematopoietic stem-cell transplants are exposed to various types of complications, including rejection and infectious diseases
The adverse effects of the different molecules used, but above all the potential drug interactions which have an effect on pharmacokinetics, pharmacodynamics, and toxicity, can be deleterious factors for transplantation outcome
There is growing in-vitro evidence that some of these interactions result in synergistic antimicrobial effects.[3]
Summary
The continuing increase in the number of patients treated with transplantation procedures is attested by a worldwide activity of more than 150 000 grafts per year, including solid-organ transplants and haem atopoietic stem-cell transplants.[1,2] Recipients of solid-organ transplants or haematopoietic stem-cell transplants are exposed to various types of complications, including rejection (mainly graft-versus-host disease) and infectious diseases (especially bacterial, viral, and fungal infections, and occasionally protozoal infections). Fungal infections in transplant recipients: pros and cons of immunosuppressive and antimicrobial treatment
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