Abstract
Bacteria in biofilms exhibited higher resistance to immune system and antibiotic treatment compared to their free living/planktonic counterparts. Hence there is a strong interest for developing new compounds with good antibiofilm activity. Herein three new Cu(II) complexes (CuL1, CuL2 and CuL3) with NNN pincer type ligands (L1-L3) were synthesized and the structures were confirmed by FT-IR, UV–Vis spectroscopy and single crystal X-ray analysis. Structural studies revealed the formation of five coordinate Cu(II) complexes with square-pyramidal geometry. All three compounds were investigated for antibiofilm activity against ESKAPE pathogens, such as Klebsiella pneumoniae, Enterococcus faecium, Acinetobacter baumanii, Pseudomonas aeruginosa, Enterobacter cloacae and Escherichia coli. Antibiofilm studies revealed that CuL1 was more effective against gram positive bacteria whereas CuL3 was more effective against gram negative bacteria. CuL2 showed least effective against all the bacteria stains. Computational docking studies of complexes with biomolecular targets revealed preferential binding with 5FCA (Enterococcus faecium).
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