Abstract
Opening of the five-member ring of indolylmethyleneoxazolones with aliphatic amines was used to synthesize a series of amides of 2-amino-3-indolylacrylic acid. These compounds were studied in vitro in relation to the various types of pharmacological activity typical of this class, including receptor (5-HT2-, 5-HT3-, and P2Y1-ergic, K-opioid), antiaggregant, hemorheological, antiarrhythmic, and antioxidant activities.
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