Abstract
Fourteen ursolic acid and oleanolic acid saponins with N-acetyl-β- d-glucosamine, and (1→4)-linked and (1→6)-linked N-acetyl-β- d-glucosamine oligosaccharide residues were synthesized in a convergent manner. The structures of all compounds were confirmed by 1H NMR and 13C NMR spectroscopy and by mass spectrometry, and their cytotoxic activities were assayed in three cancer cell lines. Only oleanolic acid-3-yl β- d-GluNAc showed significant cytotoxicity against HL-60 and BGC-823.
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