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Abstract
In this paper the new starting material 2-(5-chloro-1H-benzo[d]imidazole-2-yl) aniline (1) was synthesized by the condensation reaction of 4-chloro-o-phenylenediamine and anthranilic acid .The new Mannich base derivatives were synthesized using formaldehyde and different secondary amines to synthesize a new set of benzimidazole derivatives(2-5). Also, the new Schiff-base derivatives (6-10) were synthesized from the reaction of compound (1) with various aromatic aldehydes and the closure-ring was done successfully using mercapto acetic acid to get the new thiazolidine derivatives(11-12).These new compounds were characterized using some physical techniques like:FT-IR Spectra and 1HNMR Spectra.
Highlights
Benzimidazole is a heterocyclic aromatic organic compound
Benzimidazole derivatives have important functions in medical field with many pharmacological activities such as antimicrobial, antiviral, antidiabetic and anticancer activity.It is an important pharmacophore in drug field due to being a good bio activity of naturally forming nucleotides [2,3,4,5]
Schiff’s bases are condensation products of primary amines with carbonyl compounds and they were first known by Schiff in 1864 [9].A broad variety of benzimidazole derivatives have been well-known for their chemotherapeutic importance. for example: the presence of mannich side chains in a drug may fight the water bacteria through the formation of hydrochlorides[10],schiffs bases have anti cancer activity in animal inspection[11]
Summary
Benzimidazole is a heterocyclic aromatic organic compound. It is a Bicyclic compound composed of the fusion of benzene and imidazole. Mannich reactions have become important tools for the synthesis of new compounds. Mannich bases can either be directly used as intermediate chemical synthesis [6].They are organic compounds with the general formula R-CH2-N
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