SYNTHESIS OF SOME NOVEL TRIAZOLE DERIVATIVES AS SCHIFF BASES AND THEIR ANTIMICROBIAL EVALUATION

Abstract

<p><strong>Objective: </strong>This work involves the synthesis of some novel schiff base derivatives synthesized from <em>p-</em>amino benzoic acid.</p><p><strong>Methods: </strong>A series of 4-[4-(arylidene amino-5-mercapto-4H-[1, 2, 4] triazol-3-yl]-benzoic acid complexes were synthesized from 4-(4-amino-5-mercapto-4H-[1, 2, 4] triazol-3-yl)-benzoic acid by reaction with different aromatic aldehydes. All the synthesized schiff base derivatives were characterized by using analytical techniques (FT-IR, <sup>1</sup>H NMR and Mass spectroscopy). The title compounds were evaluated for antibacterial activity against Gram-positive bacteria (<em>Staphylococcus aureus </em>and <em>Streptococcus pneumoniae) </em>and Gram-negative bacteria (<em>Escherichia coli and Pseudomonas aeruginosa)</em> and anti-fungal activity against (<em>Candida albicans </em>and <em>Aspergillus niger).</em></p><p><strong>Results: </strong>Schiff base derivatives 5(a-h) were synthesized in good yields and showed antimicrobial activity, among them, compounds 5c, 5d, 5e and 5f were significantly active against gram positive, gram negative bacterial and fungal strains and rest of compounds showed moderate to weak activity.</p><p><strong>Conclusion: </strong>The Schiff base obtained showed variation in the antimicrobial and antifungal activity, based on the structure of the substituted aromatic aldehydes.</p>