Synthesis of New Benzoxazole Derivatives and Evaluation of their Antifungal and Antibacterial Activities

Abstract

Analytical chemistry aims to synthesize some novel benzoxazole derivatives with lower side effects and more efficacy. In this research, we synthesized the target compound’s reaction of 2- aminophenol in methanol and added carbon disulfide to obtain benzo[d] oxazole-2-thiol. This obtained compound again reacts with 4-chlorobenzoic acid to form 4-(benzo [d]oxazol-2-ylthio) benzoic acid. 4-(benzo[d]oxazol-2-ylthio) benzoic acid was further treated with substituted esters to give the crude product (4a-4e). The structures of derivatives are characterized with the help of IR, 1H NMR, TLC Spectroscopy, and melting point. The derivatives of the compounds were tested for antibacterial & antifungal activities. Antimicrobial evaluation was performed individually with gram-positive and gram-negative bacteria S. aureus and Pseudomonas aeruginosa. Aspergillus niger and Candida albicans were the two types of fungi on which antifungal activities were conducted. The outcomes were compared to those of the common medications Amphotericin B and Ciprofloxacin. It was discovered that the produced compounds have considerable antibacterial and antifungal activity. Four synthesized derivatives are named as 4 (d, b, e, c). The 4 d showed a good antimicrobial activity against the S. aureus. The 4 c showed good antifungal activities against the Candida albicans MTCC3541. The order of antifungal activity of these synthesized compounds is 4c >4e > 4b >4d. The standard. The 4 c showed a good antifungal activity against the C. albicans.